Orlistat 120 is for weight reduction in adults (18 years and above) with a body mass index (BMI) of 28 or more. Obesity, defined as excessive fat accumulation posing health risks, is indicated by a BMI over 25, with over 30 considered obese.
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Adiponil 120mg Capsule is prescribed for weight reduction in adults aged 18 years and above who are overweight, with a body mass index (BMI) of 28 or more.
Obesity, characterized by abnormal or excessive fat accumulation, poses health risks. A BMI over 25 is considered overweight, and over 30 is obese.
Before taking Adiponil 120mg Capsule, inform your doctor if you have cholestasis, malnutrition syndrome, diabetes, or kidney disease. Pregnant and breastfeeding women should avoid using Adiponil 120mg Capsule.
Additionally, it's not recommended for children and adolescents below 18 years of age. Consult your doctor before starting the medication.
Consuming alcohol with Adiponil 120mg Capsule does not cause any harmful side effects.
Adiponil 120mg Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects on the developing
Adiponil 120 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in significant amounts and is not harmful to the baby. However, use only if prescribed by a doctor.
Adiponil 120mg Capsule does not usually affect your ability to drive.
Adiponil 120mg Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Adiponil 120mg Capsule may not be needed in these patients. However, use caution as the medicine may be associated with the formation of kidney stones in patients with underlying kidney disease.
Adiponil 120mg Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Adiponil 120mg Capsule may not be needed in these patients. However, consult your doctor before use.
Anti-obesity
Adiponil 120 works by attaching to the enzymes in the digestive system (lipases) and preventing them from breaking down some of the fat that have consumed during the meal. The fat that is not digested cannot be absorbed and it is removed by the body.
Common adverse events include oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation, and fecal incontinence.
Orlistat is indicated for managing obesity, aiding in weight loss, and maintaining weight when used alongside a reduced-calorie diet. It's also prescribed to reduce the risk of weight regain after prior weight loss. Orlistat 120 mg is recommended for obese patients with an initial BMI ≥30 kg/m2 or ≥27 kg/m2 in the presence of other risk factors like hypertension, diabetes, or dyslipidemia. Orlistat 60 mg is suitable for overweight and obese patients with an initial BMI ≥25 kg/m2.
Orlistat acts as a reversible inhibitor of gastrointestinal lipase, working in the stomach and small intestine. It forms a covalent bond with the active serine residue site of gastric and pancreatic lipase, rendering them unavailable to hydrolyze dietary fat into absorbable free fatty acids and monoglycerides. The resulting caloric deficit aids in weight control.
The recommended dose is one 60 mg or 120 mg capsule taken three times daily with each main meal containing fat, either during the meal or up to 1 hour after. Patients should follow a nutritionally balanced, reduced-calorie diet with approximately 30% of calories from fat. Fat, carbohydrate, and protein intake should be distributed over three main meals. If a meal is occasionally missed or contains no fat, the dose can be omitted. Orlistat may reduce the absorption of fat-soluble vitamins and beta-carotene, so patients should take a multivitamin containing fat-soluble vitamins at least 2 hours before or after Orlistat administration.
Orlistat may reduce the absorption of iodine salts and/or levothyroxine, fat-soluble vitamins (A, D, E, K), and beta-carotene. It may decrease plasma levels of ciclosporin and amiodarone. Additionally, it may decrease the efficacy of antiepileptic drugs, antiretrovirals, antidepressants, and antipsychotics. Orlistat can also enhance the anticoagulant effect of warfarin and cause hormonal contraceptive failure.
Orlistat is contraindicated in pregnancy, chronic malabsorption syndrome, cholestasis, and known hypersensitivity to Orlistat or any component of the product.
Orlistat is Pregnancy Category X and is contraindicated during pregnancy due to potential fetal harm. It's unknown if Orlistat is present in human milk, so caution is advised when administering it to nursing women.
Patients should adhere to dietary guidelines, especially regarding fat intake, to minimize gastrointestinal events. If a meal is missed, the dose of Orlistat may be omitted.
Store below 25°C, with excursions permitted to 15° to 30°C. Keep out of reach of children.
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